The endothelial barrier refers to the protective barrier formed by endothelial cells that line blood vessels. This barrier plays a crucial role in regulating the movement of molecules and cells between the bloodstream and surrounding tissues. Disruption of the endothelial barrier can result in various pathological conditions, including inflammation, tissue damage, and vascular diseases. Research in the area of endothelial barrier focuses on understanding the mechanisms that regulate barrier integrity and function, as well as identifying potential therapeutic targets for treating conditions associated with barrier dysfunction. This research involves studying the molecular and cellular processes involved in maintaining endothelial barrier integrity, as well as the signaling pathways that control barrier permeability and repair. Additionally, researchers investigate how various factors, such as inflammation, oxidative stress, and mechanical forces, can disrupt the endothelial barrier and contribute to disease development. Overall, research in this area aims to improve our understanding of endothelial barrier function and to develop novel strategies for protecting and restoring barrier integrity in various disease states.